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It is difficult to imagine anyone who has not heard of the disease we call “cancer”. Ten million new cases are diagnosed annually worldwide, and the number is expected to increase to 20 million by the year 2020. If such trends continue, close to one out of every two people in the United States will eventually develop some form of the disease and cancer will be the most common cause of death. To put it another way, in a country of roughly 300 million people we are expecting more than 100 million new cancer cases! In the face of such numbers, it is not surprising that there is widespread interest in (and fear of) the topic of cancer biology. The good news is that enormous progress has been made in the past few decades in travelling the cellular and molecular mechanisms that underlie the development of cancer. The study of cancer biology, once restricted almost entirely to the medical school curriculum, is becoming a topic of broad relevance to biologists as they uncover the roles of various genes and their protein products in the abnormal behavior of cancer cells. As it turns out, investigating the properties of cancer cells has deepened our understanding of normal cells and, conversely, our rapidly expanding knowledge about the behavior of normal cells is providing numerous insights into the properties of cancer cells. It is reasonable to expect that our growing understanding of the principles that govern the behavior of cancer cells will eventually lead to better approaches for cancer diagnosis, treatment, and prevention. The meaning of the word cancer is based on differences in the growth patterns of tumors that allow them to be subdivided into two fundamentally different categories. One group consists of benign tumors, which grow in a confined local area. In contrast, malignant tumors can invade surrounding tissues, enter the bloodstream, and spread to distant parts of the body by a process called metastasis. The term cancer is a generic term that refers to any malignant tumor that is, any tumor capable of spreading by invasion and metastasis. Cancer is disease in which there is uncontrolled cell growth (growth and division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). Medical term for cancer is malignant neoplasm. Cancer is a disease in which abnormal cells proliferate in an uncontrolled fashion and spread through the body. Such cells can arise in a variety of tissues and organs, and each of these sites contains different cell types that may be affected. The net result is more than 100 kinds of cancer distinguished from one another on the basis of where they originate and the cell type involved.
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